0.05 Were Considered Significant. Significant Influence of Calcitriol on Calcium Set Point, Slope Significant. Tnf-a as Well as Il-1 Showed No Significant

1719 times a week were given i.v. calcitriol at the end of each and basal PTH as well as carboxy-terminal telopeptide of collagen I in haemodialysis patients. dialysis session. In the first month the received 1 mg per session , then 1.5 mg in the following month, and a mean of Furthermore, the lack of correlation between IL-6 and serum PTH, as well as TRAP values after calcitriol treatment, 2.1±0.9 mg according to Ca×P product in the 3rd month (not to exceed 70 mg/dl). Both before and after 3 months of may result from the fact that PTH levels decreased after treatment. This is in agreement with the previous suggestion calcitriol therapy the parameters of the PTH–calcium relationship curve (PTH min , PTH max –steady value, set point of [6 ] that IL-6 may mediate bone resorption, particularly in cases of severe hyperparathyroidism. calcium, slope of the curve, and PTH basal /PTH max ratio) were established for each patient according to the Felsenfeld Lublin A. J. Jaroszynski definition [2]. Serum levels of IL-1, IL-6, TNF-a and osteo-Poland A. Ksiazek calcin (BGP) were measured by ELISA. Plasma tartrate-resistant acid phosphatase (TRAP), a marker of osteoclastic activity, was measured by a colorimetric method. Group Achard J, Fournier A. The dependency of calcium set point on means were compared by Student's t test for dependent basal plasma calcium in dialysis patients: a better explanation for samples. Spearman correlation analysis was used to deter-the discrepancies regarding its link with PTH secretion than mine correlation between variables. Values for P of less than methodological differences. Results are shown in Table 1. Calcitriol administration led function as a determinant of the response to calcitriol treatment to a decrease in PTH basal, minimal, and maximal, in the hemodialysis patients. PTH basal /PTH max ratio, as well as in serum TRAP, and to 3. new analogues of vitamin D on bone cells: Implications for an increase in serum calcium and phosphorus. We found no treatment of uremic bone disease. of the curve, or serum IL-1, IL-6 and TNF-a levels. Positive Comparison of effects of calcitriol and calcium carbonate on significant correlations were observed between IL-6 and pre-secretion of interleukin-1 beta and tumour necrosis factor-alpha treatment values of PTH basal (r=0.637 P=0.018), PTH max by uraemic peripheral blood mononuclear cells. Nephrol Dial (r=0.580 P=0.031). After calcitriol treatment, correlations Z, Malluche H. Bone resorption and mRNA expression of IL-6 between …